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Original Article · Open access

The fluoroquinolones may positively affect tendon healing after surgical repair

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Tugcan Demir

Department of Orthopedics and Traumatology, Giresun University Faculty of Medicine, Giresun, Türkiye

ORCID: 0000-0002-0273-832X

Ertugrul Sener

Department of Orthopedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Türkiye

ORCID: 0000-0002-9962-1813

Akif Muhtar Öztürk

Department of Orthopedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Türkiye

ORCID: 0000-0003-3425-1206

Taner Bekmezci

Orthopedics and Traumatology, Independent Researcher, İstanbul, Türkiye

ORCID: 0000-0003-3962-2491

Erdinç Esen

Department of Orthopedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Türkiye

ORCID: 0000-0003-0434-5850

Gülnur Take Kaplanoglu

Department of Histology and Embriology, Gazi University Faculty of Medicine, Ankara, Türkiye

ORCID: 0000-0002-4321-4709

Abstract

Objectives: This study aimed to evaluate the biomechanical and histological effects of fluoroquinolones on surgically repaired tendon healing.

Materials and methods: The Achilles tendons of 40 Wistar rats (mean weight: 213.5 g; range 201 to 242 g) were bilaterally surgically cut and repaired. The rats were randomly divided into four groups: the first and third groups were designated as control groups and did not receive drug therapy, whereas the second and fourth groups received 300 mg/kg ciprofloxacin for a week after the surgical procedure. The first and second groups had both tendons dissected at the end of the first week, while the third and fourth groups were dissected at the end of the third week. The left tendons were examined biomechanically, while the right tendons were examined histologically.

Results: Statistical analysis revealed that the mean maximum tensile forces of tendons in the first and second groups were 5.2±1.84 N (range, 2.9 to 8.5 N) and 11.1±2.65 N (range, 7.3 to 13.9 N), respectively, which was found to be statistically significant (p< 0.05). At the end of the third week, mean maximum tensile forces of the third and fourth groups were determined to be 20.7±5.0 N (range, 22.1 to 29.8 N) and 28.7±4.6 N (range, 22.1 to 36.8 N), respectively, which was also statistically significant (p< 0.05). Histologically, our results were compatible.

Conclusion: This study demonstrated that ciprofloxacin did not exhibit the expected adverse effects on surgically repaired tendon healing in the early stages but likely contributed to healing in the short term by affecting the inflammatory phase.

Declarations

Ethics Committee Approval

The study protocol was approved by the Gazi University Experimental Animals Ethics Committee (date: 28.11.2005, no: 00.00/99-17097). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Author Contributions

Conceptualization, design: T.D., E.S.; Supervision, critical review: T.D., E.S., A.M.O.; Data collection and processing: T.D., E.E., T.B., G.T.K.; Analysis: T.D., E.S., A.M.O., E.E., T.B., G.T.K.; Literature reviev: T.D., A.M.O., T.B.; Writing the article: T.D.; Materials: T.D., G.T.K., A.M.O.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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